Lexus IS 350vsMercedes-Benz E350 4matic
Mercedes-Benz E350 4matic leads in City MPG (24 vs 19) and Highway MPG (33 vs 27) and 3 more.
Fuel Economy
19
City MPG
24
27
Highway MPG
33
22
Combined MPG
27
Engine & Drivetrain
6
Cylinders
4
4
Engine Displacement
2
RWD
Drive Type
AWD
Automatic
Transmission
Automatic
Premium Gasoline
Fuel Type
Premium Gasoline
Emissions & Cost
403
CO₂ Emissions
327
3,150
Annual Fuel Cost
2,550
Compact Cars
Vehicle Class
Midsize Cars
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Data sourced from EPA Fuel Economy Data (Public Domain (U.S. Government)).